Project Acronym: PoC-BoSens

Full title: Label-free PoC device based on 3D photonic Bottle microresonators for real-time high-Sensitive measurement of disease relevant biomolecules

Project duration: 2018-2021
Coordinator: Dr. Alethea Vanessa Zamora Gómez/Frauhofer IZM

Contact: alethea.vanessa.zamora.gomez@izm.fraunhofer.de

Project website address: http://www.poc-bosens.researchproject.at/index.php 

Executive summary

Each year 650,000 to 850,000 cases of Lyme Borreliosis (LB) infection are reported in the European Union. A number that is expected to rise due to the population increase of the tick “Ixodes ricinus” carrying the bacteria “Borrelia burgdorferi.” Fast detection of LB infection could drastically reduce the infected patient rate by supplying proper treatment in an earlier stage. However, insufficiencies and delays in current diagnostic methods are an obstacle to reach it.

The PoC-BoSens project aims to develop a portable diagnostic system platform for early detection of LB infected patients by using cell-based assays that rely on the quantitative determination of cytokine biomarkers. The diagnostic results of these biomarkers must be accurate, rapid (~15 minutes) and reliable. Thus Poc-BoSens proposes optical microresonators, especially bottle microresonator structures, in order to cover these requirements. Bottle resonators in combination with a biofuncionalization process and a fluidic microsystem give rise to a compact optofluidic biochip cartridge. This will be read employing a miniaturized readout device for detection of target biomarkers. The innovative PoC-BoSens technology can also be the basis for many other diagnostic applications.

A high-qualified multidisciplinary consortium is required to achieve project´s goal. The involved partners are from academia and industry: Fraunhofer IZM, Austrian Institute of Technology, Scuola Superiore Sant’Anna, MDX Devices GmbH, IFU Diagnostic Systems GmbH, Diarect AG, Scienion AG, Syel srl and Unitive Design and Analysis Ltd.